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Glutathione is a key component in mental and physical wellness at a cellular level because it helps create DNA

[4] Based on animal research, it is thought that the increased methylmalonyl-CoA hydrolyzes to form methylmalonate (methylmalonic acid), a neurotoxic dicarboxylic acid, causing neurological deterioration

"Thyroid physiology and diagnostic evaluation of patients with thyroid disorders." Williams textbook of endocrinology: 334

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PMID: 11121126 Lamb JR, Crawford ED, Peck D, et al

The correlation between 4-hydroxyestrogens and 4-methoxyestrogens seemed to be much weaker ( r = 0.003